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A vaccine for human rhinovirus for COPD and asthma exacerbations

By Richard Butt

A vaccine for human rhinovirus for COPD and asthma exacerbations

a collaboration with Prof Sebastian Johnston, Imperial College London

Prof Johnston is Professor of Respiratory Medicine & Allergy at the National Heart and Lung Institute, Imperial College London, and Honorary Consultant Physician in Respiratory Medicine & Allergy at St Mary’s Hospital, Imperial Healthcare NHS Trust, London. He is Director of the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma and is the Asthma UK Clinical Chair at Imperial College London. Prof Johnston’s work has established the viral aetiology of asthma exacerbations, demonstrated that people with asthma are more susceptible to rhinovirus infection than normal individuals, discovered novel mechanisms of susceptibility to virus infection in asthma and described novel and effective treatment approach for acute exacerbations of asthma. Apollo and Prof. Johnston will collaborate to discover and optimise recombinant HRV vaccines as a novel approach to the prevention of acute exacerbations.

Image from the RCSB PDB ( of PDB ID 1AYM (Hadfield, A.T., Lee, W., Zhao, R., Oliveira, M.A., Minor, I., Rueckert, R.R., Rossmann, M.G. (1997) The refined structure of human rhinovirus 16 at 2.15 A resolution: implications for the viral life cycle. Structure 5: 427-441) created with the NGL viewer (AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. Web-based molecular graphics for large complexes. ACM Proceedings of the 21st International Conference on Web3D Technology (Web3D ’16): 185-186, 2016. doi:10.1145/2945292.2945324
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402)